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Joined 2Y ago
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Cake day: Apr 18, 2019

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You can set it through about:config (only available on Beta and Nightly, Stable for some reason blocks access to about:config)

network.trr.mode = 3

network.trr.uri = your DoH server



By now, the process of creating custom lithium-ion battery packs is well-known enough to be within the reach of most makers. But it’s not a path without hazard, and mistakes with battery protection and management can be costly. Happily for those who are apprehensive on the battery front there’s a so…


Patch 1.23 for Cyberpunk 2077 is live on PC, consoles and Stadia. …


Hello everyone, …

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Can’t read the article, Web Archive is down and the original doesn’t exist anymore.

https://twitter.com/internetarchive/status/1404800873377583104


Saw it and pinned it, thanks! I’ll delete this one.


Here’s a copy of the article

Moderna will take mRNA flu and HIV vaccines into Phase 1 trials this year, as well as beginning a pivotal Phase 3 study for its cytomegalovirus (CMV) vaccine candidate.

A Phase 1 study for a RSV vaccine candidate is also under way.

As part of its Vaccine Day this week, the company has updated its vaccine development timeline and unveiled results from early stage mRNA vaccine trials.

HIV vaccines: mRNA-1644 and mRNA-1574

Moderna expects to begin three phase 1 clinical trials for two HIV vaccine candidates, mRNA-1644 and mRNA-1574, in 2021.

mRNA-1644 is a novel approach to HIV vaccine strategy in humans designed to elicit broadly neutralizing HIV-1 antibodies (bNAbs). It is being developed in collaboration with the International AIDS Vaccine Initiative (IAVI) and the Bill and Melinda Gates Foundation (BMGF). A Phase 1 study for the candidate will use iterative human testing to validate the approach and antigens and multiple novel antigens will be used for germline-targeting and immuno-focusing.

A second approach, mRNA-1574, is being evaluated with the US National Institutes of Health (NIH) and includes multiple native-like trimer antigens.

mRNA flu vaccine candidate: mRNA-1010

Moderna’s flu program is assessing multiple candidates, comprising multiple antigen combinations against the four seasonal viruses recommended by the WHO. The company expects to begin a Phase 1 clinical trial for the program this year.

Beyond this, it wants to explore potential combination vaccines against flu, SARS-CoV-2, RSV and human metapneumovirus (hMPV).

Current flu vaccines in the market have efficacy rates in the regoin of 40-60%: which Moderna believes its mRNA technology can improve on. It also says that its technology has several advantages over egg-based vaccine production: not only in terms of production advances but in accurately targetting vaccines against strains (egg-based production has the potential to cause unintended antigenic change to the vaccine virus).

RSV vaccine candidate: mRNA-1345

Moderna has also released the interim analysis of its Phase 1 study for mRNA-1345, its RSV vaccine candidate, this week.

A single mRNA-1345 vaccination of 50 μg (N=19) or 100 μg (N=20) was generally well-tolerated in younger adults (ages 18-49 years).

The vaccine was shown to increase RSV neutralizing antibodies in seropositive younger adults. Neutralizing antibodies were also present at baseline in all participants, as expected. A single vaccination of mRNA-1345 at the 50 or 100 μg dose level boosted neutralizing antibody titers against both serotypes of RSV-A and RSV-B with no apparent dose response.

“I am encouraged by these interim Phase 1 data showing the ability of mRNA-1345 to elicit a strong neutralizing antibody response,” said Jacqueline Miller, M.D., Senior Vice President, Infectious Diseases, Moderna. “We will continue to pursue RSV vaccines to protect the most vulnerable populations – young children and older adults – where reducing RSV infection is also a significant unmet need. We will also be evaluating possible combinations of mRNA-1345 with other respiratory virus vaccines.”

There is currently no approved vaccine for Respiratory Syncytial Virus.

CMV vaccine mRNA-1647

Moderna’s CMV vaccine is the most advanced of its mRNA vaccine candidates: and it will enter a Phase 3 pivotal study of 8,000 seronegative women aged 16-40 this year across the US, Europe and Asia-Pacific.

Moderna has released interim Phase 2 data for the vaccine, mRNA-1647, this week after seven months. In CMV-seronegative participants after 3 doses, neutralizing antibody geometric mean titers (GMTs) against epithelial cell infection were at least 20-fold higher than the baseline GMT of the CMV-seropositive group; while neutralizing antibody GMTs against fibroblast infection approximated the baseline GMT of the CMV-seropositive group.

In CMV positive participants, neutralizing antibody GMTs against epithelial cell infection increased to at least 6.8-fold over baseline, while neutralizing antibody GMTs against fibroblast infection increased to approximately 2-fold over baseline

mRNA-1647 is a vaccine combining six mRNAs in a single vial, which encode for two antigens located on the surface of CMV: five mRNAs encoding the subunits that form the membrane-bound pentamer complex and one mRNA encoding the full-length membrane-bound glycoprotein B (gB). Both the pentamer and gB are essential for CMV to infect barrier epithelial surfaces and gain access to the body. mRNA-1647 is designed to produce an immune response against both the pentamer and gB for the prevention of CMV infection.


For me iOS is not an option until they finally allow WebKit to be used as the rendering engine, and until they all addons support for other browsers.


They did manage to salvage the game, it’s a good game although a bit grindy.


Hello everyone, …

6

Update 3.5, Prisms, dramatically refreshes the No Man’s Sky experience with a range of new visual features and technologies. The universe has never looked better, with reflections, new texture effects, more biome detail, improved lighting, new skies, new warp effects,…



It’s indeed a nice tool to setup a local database and learn the basics of SQL.


Looks nice, although I wish I could buy it barebone and source the RAM and SSD myself.

That would make a nice server for my 4-bay HDD enclosure.


Hello everyone, …



There’s a Firefox Beta, Nightly is more like the Alpha version.


Hello Everyone! …


From what I understood it’s opt-in, so you don’t send anything unless you explicitly turn it on?


I hope they’ll eventually come out of beta and offer a paid version with unlimited email aliases.

I’d really like to encourage Mozilla financially through a product that helps perserve my privacy.



How do you make those non-repudiable as well as non-falsifiable while preserving the privacy of the owner?


Hello everyone, …


Hotfix 1.22 for Cyberpunk 2077 is live on PC, consoles and Stadia. …

0

For some reason the new UI does that, but logging in old.reddit.com works fine.


You’re definitely playing as Sir Kickalot in this game.


These are old but I enjoyed their combat system

  • Chronicles of Riddick : Escape from Butcher Bay
  • Dark Messiah of Might & Magic
  • Dying Light
  • Dead Island

Hotfix 1.21 for Cyberpunk 2077 is live on PC, consoles and Stadia. …


Thank you to everyone playing the Expeditions Update, especially those taking the time to report any issues they encounter via Zendesk or console crash reporting. …


Fingers crossed that Sony publishes a firmware update that fix this behavior. Maybe I should change the battery in mine before they pull the plug?


I hope they’ll also backtrack on their idea of disabling about:config on Firefox Stable for Android eventually.


I’ll state the obvious, you should never use your Bitwarden vault password anywhere else, and also use 2FA for it. You don’t want Bitwarden itself to be your weakest link, considering it literally holds the keys to your entire digital kingdom.


Too bad, I was hoping they’d eventually release a version suited to the Chromecast with Google TV :(