If you use your distro’s up-to-date built and packaged from source applications it’s unlikely you’ll have a problem. Those start when you want to use old packages or packages from a different distro (with different or patched libs) with your system.

Flatpak, AppImage etc. packaged apps will run on (almost) any system and you only need to build them for different processor architectures. So it’s the ovious choice for lazy or profit oriented developers.