• Wertheimer [any]@hexbear.netEnglish
    98·
    28 days ago

    I know not with what drugs Type 3 Diabetes will be fought, but Type 4 Diabetes will be fought with sticks and stones.

        • Hexboare [they/them]@hexbear.netEnglish
          8·
          27 days ago

          Amphetamine was the original (safe) weight loss drug due to it increasing metabolism and suppressing appetite.

          Phentermine and fenfluramine are basically worse amphetamines to achieve a similar effect.

          The appetite suppression will be less noticeable for many people with ADHD because you could be forgetting to eat and then overeating later when you feel like you’re starving

  • macabrett[they/them]English
    15·
    27 days ago

    I’ve actually been traveling the world collecting all of the Diabetes. There’s 7 of them and when you get them Ronald McDonald shows up and grants you a wish.

    • xiaohongshu [none/use name]@hexbear.netEnglish
      18·
      27 days ago

      Weight loss treatment with GLP-1 is five times the dosage administered to diabetic patients.

      It is still far too early to tell if there are long term adverse effects to the people who take them at this level of dosage yet. It’s like taking 5 times the amount of drugs you normally would when prescribed by the physicians, and you have to keep taking them since the effect (lowering appetite and slowing food digestion) is reversible once you stop taking them.

      For clinically obese patients, the benefits of weight loss are probably going to outweigh the adverse consequences, but there have been many people who don’t meet the medical criteria and are taking them just for the sake of losing weight.

      • Hexboare [they/them]@hexbear.netEnglish
        7·
        27 days ago

        I understand that the dosages of semaglutide for diabetes range from 0.25mg to 2mg - are you saying people are injecting 10mg a week? That does seem like a considerable leap

        Th lifetime usage aspect makes them particularly attractive for pharma companies

        • xiaohongshu [none/use name]@hexbear.netEnglish
          3·
          27 days ago

          All SUSTAIN trials were performed at 0.5mg or 1.0mg, where glycemic control was largely achieved with 0.5mg dose, except for severe patients where lower dosage was inadequate to reach the HbA1c target.

          STEP trials for weight loss were done with 2.4mg per week, which is 5 times the dosage normally prescribed for Type 2 diabetes patients.

          • Hexboare [they/them]@hexbear.netEnglish
            2·
            27 days ago

            Yeah they did another trial (SUSTAIN FORTE) for diabetes after those

            Semaglutide is an effective treatment for type 2 diabetes; however, 20–30% of patients given semaglutide 1·0 mg do not reach glycaemic treatment goals. We aimed to investigate the efficacy and safety of once-weekly semaglutide 2·0 mg versus 1·0 mg in adults with inadequately controlled type 2 diabetes

            10.1016/S2213-8587(21)00174-1

            • xiaohongshu [none/use name]@hexbear.netEnglish
              2·
              27 days ago

              Yes, one trial in the last 5 years. Which is why I said we’re nowhere close to knowing the long term effect of these dosage. The first SUSTAIN goes back to 2014 and we have about a decade of data. All the STEP trials are within 5 years.

              You should also note that going from 1.0mg to 2.0mg (doubling the dosage) improved the HbA1c measure from 1.9% reduction to 2.1%. It’s statistically significant but the effect is also small (an improvement for treating severe patients but not so much for the rest of the disease population). Most of the reduction is in the body weight when increasing the dosage.

              • Hexboare [they/them]@hexbear.netEnglish
                1·
                27 days ago

                Right, but the weight loss increase was also very small

                Mean change in bodyweight from baseline at week 40 was −6·9 kg with semaglutide 2·0 mg and −6·0 kg with semaglutide 1·0 mg

                So glycated haemoglobin improves by 10 percent and weight loss increase by 15 percent.

                This would suggest to me that whatever long term problems are associated with semaglutide at 2mg are probably going to be associated with semaglutide at 1mg at broadly similar rates.

                Time will tell though!

    • RNAi [he/him]@hexbear.netOPEnglish
      10·
      27 days ago

      I don’t wanna be a -truther, I’m just paranoic of the thing being abused/misused cuz right now everyone is getting a prescription for it cuz it’s the magic treatment for weight loss.

      I just don’t want a Opioid Epidemic: Pancreas Shenanigangs Boogaloo

      • Hexboare [they/them]@hexbear.netEnglish
        9·
        27 days ago

        All drugs carry some level of risk, and there are enough rare side effects that you’d want a good reason to take anything, because otherwise you might end up as “Case Report: Rare instance of dissolved organs in 40 year old male treated with semaglutide for weight loss”, which would be unfortunate.

  • GaveUp [she/her]@hexbear.netEnglish
    91·
    27 days ago

    Is there any evidence it’s bad though? There’s so much incredible modern medicine that has absolutely no downsides or side effects for 99.99% of the population, like vaccines

    • sgtlion [any]@hexbear.netEnglish
      16·
      27 days ago

      There’s so much incredible modern medicine that has absolutely no downsides or side effects for 99.99% of the population

      This is just wrong to the point of being harmful misinformation.

      Vaccines are probably the most amazing medicine, but they have (usually minor) side effects for basically everyone. I’m not aware of any medicine that doesn’t.

      • GaveUp [she/her]@hexbear.netEnglish
        10·
        27 days ago

        but they have (usually minor) side effects for basically everyone

        I meant side effects near the magnitude of “type 4 diabetes” haha

    • TraschcanOfIdeology [they/them, comrade/them]@hexbear.netEnglish
      14·
      27 days ago

      There’s so much incredible modern medicine that has absolutely no downsides or side effects for 99.99% of the population, like vaccines

      There’s also the precautionary principle, which I think is the best way to approach food and drug safety: the thing in question has to be proven to be safe and contingencies have to be in place in case of harm before being released. This is opposed to the more US approach to food and drug safety, which requires proof that the thing is unsafe to proceed with regulation.