• Wertheimer [any]@hexbear.netEnglish
    98·
    2 months ago

    I know not with what drugs Type 3 Diabetes will be fought, but Type 4 Diabetes will be fought with sticks and stones.

        • Hexboare [they/them]@hexbear.netEnglish
          8·
          2 months ago

          Amphetamine was the original (safe) weight loss drug due to it increasing metabolism and suppressing appetite.

          Phentermine and fenfluramine are basically worse amphetamines to achieve a similar effect.

          The appetite suppression will be less noticeable for many people with ADHD because you could be forgetting to eat and then overeating later when you feel like you’re starving

  • macabrett[they/them]English
    15·
    2 months ago

    I’ve actually been traveling the world collecting all of the Diabetes. There’s 7 of them and when you get them Ronald McDonald shows up and grants you a wish.

      • Hexboare [they/them]@hexbear.netEnglish
        7·
        2 months ago

        I understand that the dosages of semaglutide for diabetes range from 0.25mg to 2mg - are you saying people are injecting 10mg a week? That does seem like a considerable leap

        Th lifetime usage aspect makes them particularly attractive for pharma companies

          • Hexboare [they/them]@hexbear.netEnglish
            2·
            2 months ago

            Yeah they did another trial (SUSTAIN FORTE) for diabetes after those

            Semaglutide is an effective treatment for type 2 diabetes; however, 20–30% of patients given semaglutide 1·0 mg do not reach glycaemic treatment goals. We aimed to investigate the efficacy and safety of once-weekly semaglutide 2·0 mg versus 1·0 mg in adults with inadequately controlled type 2 diabetes

            10.1016/S2213-8587(21)00174-1

              • Hexboare [they/them]@hexbear.netEnglish
                1·
                2 months ago

                Right, but the weight loss increase was also very small

                Mean change in bodyweight from baseline at week 40 was −6·9 kg with semaglutide 2·0 mg and −6·0 kg with semaglutide 1·0 mg

                So glycated haemoglobin improves by 10 percent and weight loss increase by 15 percent.

                This would suggest to me that whatever long term problems are associated with semaglutide at 2mg are probably going to be associated with semaglutide at 1mg at broadly similar rates.

                Time will tell though!

    • RNAi [he/him]@hexbear.netOPEnglish
      10·
      2 months ago

      I don’t wanna be a -truther, I’m just paranoic of the thing being abused/misused cuz right now everyone is getting a prescription for it cuz it’s the magic treatment for weight loss.

      I just don’t want a Opioid Epidemic: Pancreas Shenanigangs Boogaloo

      • Hexboare [they/them]@hexbear.netEnglish
        9·
        2 months ago

        All drugs carry some level of risk, and there are enough rare side effects that you’d want a good reason to take anything, because otherwise you might end up as “Case Report: Rare instance of dissolved organs in 40 year old male treated with semaglutide for weight loss”, which would be unfortunate.

  • GaveUp [she/her]@hexbear.netEnglish
    91·
    2 months ago

    Is there any evidence it’s bad though? There’s so much incredible modern medicine that has absolutely no downsides or side effects for 99.99% of the population, like vaccines

    • sgtlion [any]@hexbear.netEnglish
      16·
      2 months ago

      There’s so much incredible modern medicine that has absolutely no downsides or side effects for 99.99% of the population

      This is just wrong to the point of being harmful misinformation.

      Vaccines are probably the most amazing medicine, but they have (usually minor) side effects for basically everyone. I’m not aware of any medicine that doesn’t.

      • GaveUp [she/her]@hexbear.netEnglish
        10·
        2 months ago

        but they have (usually minor) side effects for basically everyone

        I meant side effects near the magnitude of “type 4 diabetes” haha

    • TraschcanOfIdeology [they/them, comrade/them]@hexbear.netEnglish
      14·
      2 months ago

      There’s so much incredible modern medicine that has absolutely no downsides or side effects for 99.99% of the population, like vaccines

      There’s also the precautionary principle, which I think is the best way to approach food and drug safety: the thing in question has to be proven to be safe and contingencies have to be in place in case of harm before being released. This is opposed to the more US approach to food and drug safety, which requires proof that the thing is unsafe to proceed with regulation.