• Hexboare [they/them]@hexbear.net
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        2 months ago

        I understand that the dosages of semaglutide for diabetes range from 0.25mg to 2mg - are you saying people are injecting 10mg a week? That does seem like a considerable leap

        Th lifetime usage aspect makes them particularly attractive for pharma companies

          • Hexboare [they/them]@hexbear.net
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            2 months ago

            Yeah they did another trial (SUSTAIN FORTE) for diabetes after those

            Semaglutide is an effective treatment for type 2 diabetes; however, 20–30% of patients given semaglutide 1·0 mg do not reach glycaemic treatment goals. We aimed to investigate the efficacy and safety of once-weekly semaglutide 2·0 mg versus 1·0 mg in adults with inadequately controlled type 2 diabetes

            10.1016/S2213-8587(21)00174-1

              • Hexboare [they/them]@hexbear.net
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                2 months ago

                Right, but the weight loss increase was also very small

                Mean change in bodyweight from baseline at week 40 was −6·9 kg with semaglutide 2·0 mg and −6·0 kg with semaglutide 1·0 mg

                So glycated haemoglobin improves by 10 percent and weight loss increase by 15 percent.

                This would suggest to me that whatever long term problems are associated with semaglutide at 2mg are probably going to be associated with semaglutide at 1mg at broadly similar rates.

                Time will tell though!

    • RNAi [he/him]@hexbear.netOP
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      2 months ago

      I don’t wanna be a -truther, I’m just paranoic of the thing being abused/misused cuz right now everyone is getting a prescription for it cuz it’s the magic treatment for weight loss.

      I just don’t want a Opioid Epidemic: Pancreas Shenanigangs Boogaloo

      • Hexboare [they/them]@hexbear.net
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        2 months ago

        All drugs carry some level of risk, and there are enough rare side effects that you’d want a good reason to take anything, because otherwise you might end up as “Case Report: Rare instance of dissolved organs in 40 year old male treated with semaglutide for weight loss”, which would be unfortunate.