Right, but the weight loss increase was also very small

Mean change in bodyweight from baseline at week 40 was −6·9 kg with semaglutide 2·0 mg and −6·0 kg with semaglutide 1·0 mg

So glycated haemoglobin improves by 10 percent and weight loss increase by 15 percent.

This would suggest to me that whatever long term problems are associated with semaglutide at 2mg are probably going to be associated with semaglutide at 1mg at broadly similar rates.

Time will tell though!