With all the hormones and whatnot inside. Dopamine, adrenaline, melatonin, whatever. Also, there’s this Hunter S. Thompson bit on the… pineal gland?
If it had an effect on you, wouldn’t it be a really messed up high, all over the place? With uppers, downers etc mixed? (Not including the emotional implications of eating raw human brains.)
It’s a good way to get prion disease for sure.
Are those the ones that give “laughing disease” or whatever it’s called - that’s in fact very deadly
Not sure about that but it is a great way to get Kuru
Risk factor: cannibalism Prevention: Avoid cannibalism
That sounds too difficult
It’s easy when you put your mind to it.
Often takes years or even decades for symptoms to appear after exposure
Oh jolly, everything about this resembles the Mad Cow Disease
[…]
The epidemic likely started when a villager developed sporadic Creutzfeldt–Jakob disease and died. When villagers ate the brain, they contracted the disease and then spread it to other villagers who ate their infected brains.
Jolly
It’s a prion disease. Mad Cow, Creutzfeldt-Jacob, Chronic Wasting (so far only seen in deer), and Scrapies (known of for a long time and so far limited to sheep and goats) all start with a misfolded protein and gradually break down the brain till it looks like a sponge.
And Chronic Wasting Disease (CWD) in cervids such as deer, moose, and elk, which thankfully has not been shown to be transmissible to humans yet. Prions are the stuff of nightmares.
Oh, and Fatal Familial Insomnia.
Specifically a spongiform encephalopathy. Completely incurable and universally fatal. If you contract a prion disease medical science can only ever prolong the inevitable, and it is extremely unlikely that will ever change barring some unknown hyper futuristic nano-machine technology.
It resembles mad cow disease because they’re both prion diseases, which are more or less only spread by consumption of brain.
Some of the other nasty ones that keep my a little freaked out are Chronic wasting disease, aka the zombie deer disease and Fatal Insomnia , which just sounds like something straight from a horror film.
…. Just why would they do that tho?
As part of mourning people would eat parts of dead family members.
Also alot of people who find out about this think you’ll get it from eating just anyone’s brain but the chance of developing the initial desiese is literally one in a milion, not that you should go around eating brains
Maybe the dead guy was rich
To get high
What’s with your use of the word “jolly?”
Either facetious or maybe they have some fava beans laying around.
And a nice Chianti.
Jolly
Brits try human brains for first time!
Did anyone else learn about Kuru from the Book of Eli movie?
For me, it was the game Dead Island
That wikipedia article reads like an a try in the sco wiki.
Nah, it’s the other way around, you’d have to be really fucking high to wanna eat human brains
Like… Bath salts high.
no your stomach acid would denature most of the proteins, then they’d be conjugated at the liver so whatever goes in will be transformed by what comes out. A lot of those hormones are tightly regulated so I’m thinking even if they make it into circulation they’d be eliminated fairly quickly. Only exception would be if they’re acid stable, not impacted on their way through the gut/metabolised by microbiota, absorbed in tact and still active after the first pass effect. Also theres enzymes like trypsin in your stomach that are specifically for degrading proteins so I doubt it would make you anything other than a canibal.
Would smoking raw human brains make you high?
Wait no thermal degredation
Would nebulizing raw human brains make you high? Especially of I got a little brain-diffuser in the corner that just filled the room with the aroma
Get me some brains and I’ll let you know.
Okay, hear me out. Rectal route?
Boofing brain
…And I’m done. No beating this today.
Coward. I’ll beat to this.
Boofing 2: Brain Boogaloo
It would still go through the liver for metabolism. The only thing “boofing” effectively does is skip the stomach part of the digestive process. To take up anything from the digestive tract, it gets transported through the intestinal lumen and into the mesenteric and hepatic portal system. The liver filters everything that gets into the blood from the gut before it goes into the inferior vena cava and into the rest of the circulatory system.
Correction to clarify: the lower gut/colon mostly only takes up water and certain vitamins that are released by gut bacteria, and very small molecules like ethanol can sometimes get through as well. The very lowest part of the colon does have a vascular supply that can bypass the liver, and there are some medications designed to take advantage of the select receptors and transporters down there. However, neurotransmitters and peptide hormones (which is what OP was asking about) would likely not get taken up until it was much higher up in the digestive tract, and at that point it would go through the hepatic portal system.
Thank you to those that corrected me. Intestines are actually fairly complicated.
I don’t think that’s correct.
Does rectal have first-pass effect? In general, drug absorption in the upper part of the rectum is transported to the liver via the portal system and thus undergoes first-pass metabolism, whereas drug absorption in the lower rectum is transported directly to the systemic circulation
The lower colon really only transports water and a couple of vitamins released by gut biota, so if they’re getting far enough in that more complex molecules would be taken up, that would probably be up into the hepatic portal system.
The reason “boofing” works for alcohol is because ethanol is actually a rather small molecule, all things considered.
you’re mostly right, however trypsin is produced in the pancreas and excreted into the duodenum, so not in the stomach. I think maybe you’re thinking of pepsin?
Ya it was the first one to pop into my head as an example, the main point is anything active would be neutralized one way or another by the time it ended up in circulation.
yeah i agree.
conjugated???
The liver “conjugates”/metabolises a bunch of stuff, its been almost a decade since I studied this stuff but bassically it will remove or add functional groups on/off a given compound. Most of what you eat heads straight to the liver for “processing” where food (and orally administered drugs) get altered prior to circulation. Its part of the first pass effect.
…so how many brains would i have to inject to get high?
Simplifying the question a bit:
-
Which hormones can be absorbed when eaten, and what effects would you feel
-
At what concentration are those found in the brain
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As far as the pineal gland goes, a book written in 2000 (DMT: The Spirit Molecule) declares the pineal gland produces enough DMT (Dimethyltryptamine) to experience hallucinogenic effects but this has not been confirmed, trace amounts of DMT has been found in the pineal glands of rats, but not humans. If there was enough DMT in a pineal gland and you ate it, you would also need to inhibit certain enzymes that break it down, namely, Monoamine Oxidase.
You seem to be a very well educated Fleshtrap! Thanks!
that is a common story that most people know
i bet a lot of people know more than you due to the question that you asked being very far off base from how anything actually works
brain when consumed digests so if any chemicals were still there theyd have been metabolized into something different including dmt probably but im not sure if dmt is bioavailable in the stomach
Look at the community you’re in asshole
Having absolutely no formal knowledge, I doubt it. The brain afaik is mostly fat…We also evolved eating animals we hunted and we didn’t just eat the meat. We ate the organs, liver, brain, etc. The liver is really full of that stuff and doesn’t make us high.
Yeah. Cows are way bigger than us. If we got high eating brains we would know from eating animal brains.
Why would you think it’s appropriate to comment if you’re just guessing? This is not a question where random guessing is appropriate.
Your reasoning is correct in that we do eat brains, and of course they don’t get us high.
You’re wrong is the fact that brain is mostly fat. That’s incredibly misleading. The brain is entirely nervous tissue plus supporting things like vessels. It does contain lots of myelin which serves to insulate axons, since nervous tissue is electrical. Myelin happens to contain a lot of fatty acids, but it is in no sense “fat”.
Question OP, were you high when you thought about this?
Shamefully, no. I was pondering my melatonin fruit gummies after lots of coffee, though. Coffee tends to get me a bit high sometimes. (I hadn’t eaten any gummies after the coffee, I was just thinking about them.)
melatonin is a horomone and doesnt get you high just regulates how you should sleep
coffee or caffeine inhibits your bodies ability to relax ur muscles (by mimicking adenosine i think) but doesnt make you high or more awake (like people seem to think). could cause a heart attack tho but that’s super rare if ur a normal person.
i take it you havent dabbled much in the drug world, so id remain ignorant. its more blissful. but if you really want to dabble please research yourself and not news articles. actual studies. news articles will lie and propagate misinfo.
I have a bevy of prior drug experience and still consider the way excess caffeine makes me feel to be what my idea of a mild high is.
The mind and body work hand in hand. Change one and the other feels it!
That’s how you become a Wendigo.
Even if it was legal and ethical, don’t eat far-left’s. You’ll be so woke you will regret it.
