Understanding the molecular changes underlying aging is important for developing biomarkers and healthy aging interventions. In this study, the authors used comprehensive multi-omics data to reveal nonlinear molecular profiles across chronological ages, highlighting two substantial variations observed around ages 40 and 60, which are linked to increased disease risks.

The study indicates that human aging happens in two accelerated bursts, at ages 44 and 60. Most molecules studied showed non-linear changes at these ages. These changes are associated with reduced ability to metabolize caffeine and alcohol, muscle injuries, fat accumulation, and increased susceptibility to cardiovascular disorders, kidney issues, and type 2 diabetes. The study suggests making lifestyle changes like drinking less alcohol and exercising more when nearing these ages.