Researchers at the National Institutes of Health have identified antibodies targeting a hard-to-spot region of the influenza virus, shedding light on the relatively unexplored “dark side” of the neuraminidase (NA) protein head. The antibodies target a region of the NA protein that is common among many influenza viruses, including H3N2 subtype viruses, and could be a new target for countermeasures. The research, led by scientists at the National Institute of Allergy and Infectious Diseases’ Vaccine Research Center, part of NIH, was published today in Immunity.
There’s a dark side? Like in Star Wars?
The dark side here is a reference to the underside of the neuraminidase (NA) protein head. It’s a conserved region of the virus as, while influenza is notorious for it’s continuous mutations thanks to the segmented genome, a viral capsid and glycoproteins are always kept together during reassortment. So, if we can figure out how to make vaccines which target this conserved protein, it will function against most influenza strains, rather than having researchers make educated guesses as to which strains will be most prominent each flu season. Not as cool as start wars, but still super rad!!
Haha thanks for the quick summary! I made my post as a joke. The line is from a movie called Master of Disguise.