Study by Prof. Sason Shaik from the Hebrew University of Jerusalem and Dr. Kshatresh Dutta Dubey from Shiv Nadar University reveals that Cytochromes P450 (CYP450s) enzymes can sense and respond to stimuli, acting like soft robots in living systems.Study reveals an important discovery in the realm of nanomachines within living systems. Prof. Sason Shaik from the Hebrew University of Jerusalem and Dr.
Edit: Not sure why the original link is no longer working, but heres an alternative
Van der Waals is the attraction aspect of LDF, while steric repulsion is the flipside and still a part of LDF interactions. But based on the possible substrates LDF interaction with CYP450, the active site + mechanism of action will adjust to work with what’s around. Not just an allosteric aspect where a select few molecules can fit in the active site. Or at least that’s my understanding of the study’s findings.
Edit: The 4D aspect is referencing the LDF impact on the enzymes shape and function. LDF impacts all biochem reactions, dipole and hydrophobic forces are a bigger aspect to substrate binding though. But this breaks the mold of what we thought we knew about enzymes and opens the door for a more indepth understanding of biochemical reactions.
Van der Waals is the attraction aspect of LDF, while steric repulsion is the flipside and still a part of LDF interactions. But based on the possible substrates LDF interaction with CYP450, the active site + mechanism of action will adjust to work with what’s around. Not just an allosteric aspect where a select few molecules can fit in the active site. Or at least that’s my understanding of the study’s findings.
Edit: The 4D aspect is referencing the LDF impact on the enzymes shape and function. LDF impacts all biochem reactions, dipole and hydrophobic forces are a bigger aspect to substrate binding though. But this breaks the mold of what we thought we knew about enzymes and opens the door for a more indepth understanding of biochemical reactions.
I see, thanks for the explanations :)