My preferred setup is to use Ardour as my DAW. It can take some getting used to as it has so many settings and features but the power it provides should accommodate even your most audacious requirements. For synths, I mostly uses Vitalium because I understand it the best and I find the GUI intuitive. There are many other options though such as ZenSubFx (name might be slightly wrong as i haven’t used it in a while) or Helm. I’ve found Geonkick works well for drums although my confidence in their software has diminished recently due to them changing the plugin identifier which broke projects using that plugin. Other plugins include the Calf suite, AVX suite, noise repellent and butterfly reverb. I generally prefer LV2 plugins when there are options as they tend to be more stable in my experience. Also as mentioned, definitely install Pipewire. It is a drop in replacement for Pulseaudio and will let you use more features in your DAW and lower the latency. Make sure to install pipewire-jack if you choose Ardour, as the Jack2 integration works the best.

For more info on this and an Ardour masterclass, check out Unfa on YouTube or Odysee. His website with all links is https://unfa.xyz. Have fun!