like what is the actual meaningful gain here? will i actually notice any difference? ooh i love monitoring my folate levels

  • ryannathans@lemmy.fmhy.net
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    1 year ago

    I have homozygous C677T mutations in my MTHFR gene, with homozygous COMT mutations further limiting neurotransmitter regulation. I feel very different when consuming foods high in activated folates, or related vitamins/supplements.

    • PostmodernPythia@lemmy.world
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      1 year ago

      I have the same mutations. In me they caused severe depression for almost 20 years. Started megadosing l-methylfolate, and I wanted to live again practically overnight. So yeah, it can def make you feel different.

      • OceanSoap
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        1 year ago

        Hey, I found my people! I also megadose methylfolate, and that combined with Cymbalta completely cleared up my lifelong brain fog and severe anxiety. The depressed is still here, but it’s subtle and manageable. 100% was like night and day for me. Went back to collage and got a degree and everything. Learning wasn’t such a struggle for me.