I would guess one with backbone could gum up the works for a short while. The CR, Republicans and establishment Democrats are the most immediate threat, that I can see.

Complicit in fascism? They keep confirming the absolute worst cabinet and court picks, trying nothing but Kente cloths and trying to keep insider trading privileges while Martha Stewart with a paltry billion or so dollars at the time of her conviction, which apparently cut that worth in less than half, today, according to this Yahoo article, which was just the first return on a brief search.