Her study found the glymphatic clearance was mediated by a hormone called norepinephrine and happened almost exclusively during the NREM sleep phase. But it only worked when sleep was natural. Anesthesia and sleeping pills shut this process down nearly completely.
Eff. I require sleeping pills. I guess I can look forward to a melted brain in old age.
What about alcohol?
This has been fairly well known for at least 15 years among medi-academia. But discovering the specific pathways involved leaves me (femininely) turgid
The study was only on zolpidem. IMO it can probably be generalised to other Z drugs, and possibly benzos. Drugs that work by entirely different mechanisms like melatonin and orexin antagonists could be completely different.
What about Benadryl?
The hat man cleans your brain for you.
Unknown, but it’s an anticholinergic, and those are associated with dementia.
I wonder if ketamine has the same effect, he asked apropos of nothing…
Fuck.
Now what?
That usually helps me sleep better too
Apparently the water supply in my town is dosed with sleeping pills.
Honestly, it might be. When people pee, that toilet water goes somewhere.
