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  • PopPrincess [she/her]@hexbear.net
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    27 days ago

    Anyone here who has experience using pioglitazone for better fat redistribution? I finally managed to source some and I’m quite excited to try it out meow-bounce

    • EstraDoll [she/her]@hexbear.net
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      27 days ago

      I have literally never heard of that before but tell me more. I’ve always hated my body fat distribution and want that to move ASAP

      • PopPrincess [she/her]@hexbear.net
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        27 days ago

        From my understanding, it makes it so that new weight you gain goes to your lower regions, i.e. buttocks, thighs, etc. So you have to gain weight while using it, but it can have some pretty bad side effects so make sure to read up on those before trying it. I found a decent writeup about it on reddit I can send you.

      • PopPrincess [she/her]@hexbear.net
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        27 days ago

        Omg I’ve been looking for that page for some time. I read it a while ago, but couldn’t find it again.

        I’ve seen some people mention that the results stayed after stopping pio. I guess it makes sense since the adipose cells go to the places that are in line with a female fat distribution so as long as you stay on HRT I’d assume it to stay.

        I’ll definitely report back when after I try it. My plan is to switch back to DIY injections, and then try prog and pio for about 3 months while putting on like 10-20 lbs, but first I need to spoof my blood test so the gender clinic doesn’t know what I’m doing😅

      • PopPrincess [she/her]@hexbear.net
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        27 days ago

        Oh and I definitely dont’t think it’s safe long term. Some of the side effects are bladder cancer, bone density issues and heart failure.

        Pio seems to interact with mesenchymal stem cells and a study (though not done on humans) showed transdifferentation of bone marrow mesenchymal stem cells into adipose cells IIRC. Mesenchymal stem cells also act as the prescursor to many other cells such as muscle and cartilage cells, so it’s probably not too good to affect those too much😅