I often take painkillers (acetaminophen aka paracetamol), but I’ve noticed that it’s much more effective if I take them TOGETHER with my ADHD medication (ritalin aka methylphenidate) + my morning coffee. If I don’t take them AT the same time, the painkiller is far less effective.
I do not exceed the maximum dosage of painkiller (1gram per intake, mornings), but alone this would barely suffice to kill my morning headache.
My hypothesis is that since the LIVER has to convert all three, I am effectively overdosing on either substance (painkiller or ADHD meds), and damaging my liver in the process.
The liver has different enzymes to break different molecules, so those drugs might all use different ones, not slowing down the breakdown of others. I didn’t check. Wikipedia usually tells drug metabolism in detail.
Good point. I’ll check. Though I’m not sure if that is the only point of relevance. What if the overal ‘output’ of the liver is still exceeded? Aka it’s just working overtime producing those different enzymes.