I will be ok with whatever you choose, whether that is staying federated, starting a conversation with their admins and withholding judgement until after that, defederating, or something else.

Personally, I’m not a fan of those things you have found (transphobia, misinfo, etc.), but I understand that people like that exist. I at least can block them and the communities that spout that trash.

It’s your instance, your hardware, and I trust your judgement.