After the creation of the world and during the times when humanity was in a primitive state, they only had natural herbs and magic rituals to deal with their medical ailments. One day, an old and decrepit man approached the flowermaker and said “Oh Flowermaker, I am suffering from back pain, I have fallen and I can’t get up!” He came down to the world and picked the pods of poppies, extracted a white liquid from them and took it through a primitive process of opiate extraction before giving the man a tincture. He was free of pain, but the Flowermaker warned him of addiction and dependence if the medicine of poppies was abused. The man showed humanity how to make opium, where it was used in medicine for decades until its abuse became rampant.
The British Empire started using Opium for money, and promoting its abuse in Asia where millions died from the plant. Other similar places such as the modern United States also had pharmaceutical companies that caused addiction to concentrated opiates prescribed for pain in various medications. These medicines were abused, snorted, and prescribed in higher and higher doses until humanity suffered from addictions. From this point on, the gods were hesitant to give any more medicines to humanity if they had potential for addiction.