I use Android Tiers, Glittertech (no surgery), and Rimatomics. My colonies always end up with just the most insane defenses with super powered androids.
Anyone who makes their way to my colony will find the most lavish place on the rim.
*We may or may not be using human hearts to till our soil.
I often keep playing in the same chunk, over and over, and periodically send older colonists to the space.
A big psychite farm is also always a given. My rational brain knows the meaning of the words “wealth management”, but my playing hands don’t.
I don’t do organ farming for main profit. It’s just a way to maximise the output of the raiders. They feel so much like DF goblinite, it would be a waste to let their corpses decompose. Eventually my base is full of human leather sofas, but people would wear more protective gear instead.
Currently I’m also running an eugenics project, with Biotech and a custom xenotype (cat race). My idea is to create ubercolonists out of the six races with inheritable genes. Might become a staple of my playthroughs.