With 3D printers like the Open-5x or tool changers (e.g. Prusa XL) both, 5-axis simultaneous 3D-printing as well as hybrid manufacturing (additive followed up by subtractive), is more accessible than they ever were.
For those already venturing into this endeavor: What is your toolchain/software?
Currently, I finish the additive/3D print before running a second gcode for the subtractive part (contact surfaces, threads, …). This is far from an efficient and powerful process.
There is the E3D ASMBL script for Fusion360: https://github.com/AndyEveritt/ASMBL?tab=readme-ov-file The best software I know right now but still not perfect. e.g. Printing sections that will be machined oversized so they can be machined to size.