Pathfinder 2e:

• Instead of move, standard and bonus action pathfinder 2e has just 3 actions. Attack takes an action, move takes an action, most spells takes two actions, and some abilities require all three.
• Degree of success determined by how much you meet/miss DC: if you succeed by 10 more it is critical success, if you fail by 10 or more it is critical failure. Natural one and natural 20 nudge degree of success by one in corresponding directions: crit fail <-> fail <-> success <-> crit success. Most checks have different results for each of those.
• Instead of advantage/disadvantage you gain flat bonuses/penalties of 3 categories. Combined with previous rule heavily stacked bonuses could bring 5% crit chance to something as absurd as 50%.
• Attack actions are very impactful, but then you repeat them each following attack takes a significant penalty. This breaks monotony of combat there everyone uses they strongest actions all day long, and having to opt to different choices. Often best choice for 3 action is too aid your ally in some way, and I really enjoy emphasis on teamwork.

Together those rules combine into two intertwined combat puzzles of

• applying bonuses to your team/denying them from enemies
• managing your actions/disrupting enemy action flow

System itself is more coherent, and codified it traits, removing a lot of GM fiat from adjudicating combat. This is not necessary good or bad, as some groups enjoy tactical combat, while others much prefer to just narrate and see what happens. (Although IMO dnd 5e is actually much closer to being codified then free-flow) Then making a video game tho you will need to codify game rules into consistent well communicated mechanics, and building on top of system which offers it from the start is definitely an advantage.