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Cake day: July 4th, 2023

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  • You can buy a cheap Chinese HT like a Quansheng UV-K6 for like $40. These have open firmware and there’s a bunch of custom options radio nerds have whipped up. Get the USB programming cable even if you’re not doing custom FW, makes programming frequencies and tweaking options much easier. You’ll also need a license and in the US, HamStudy.org has the exact questions from the test. There’s a ton of YouTube channels you can watch and books you can read for general purpose radio knowledge. Then it’s just a matter of getting a proper antenna and pointing it in the right place at the right time; there’s free resources online, paid apps, all that is out there and it’s just a matter of wanting to learn it. The actual hardware you need to get started is really cheap these days.








  • The cone snail referenced in the study you linked, Conus geographus, also has the same ion channel disrupting venom that is typical of cone snails. If you were bit by one, you’d die of paralysis. It does appear to use an insulin-like peptide to initially stun the fish, but the coup de grâce is from typical paralytic conotoxins.

    A cool discovery nonetheless and TIL. Neat.

    https://pubmed.ncbi.nlm.nih.gov/25301479/

    Conus geographus is the most dangerous cone snail species known, with reported human fatality rates as high as 65%. Crude venom gland extracts have been used to determine animal LD50 and to aid the isolation of several potent paralytic toxins. […]The molecular composition of individual defense-evoked venom showed significant intraspecific variations, but a core of paralytic conotoxins including α-GI, α-GII, μ-GIIIA, ω-GVIA and ω-GVIIA was always present in large amounts, consistent with the symptomology and high fatality rate in humans.



  • deranger@sh.itjust.workstoScience Memes@mander.xyzCone snails
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    6 days ago

    I’m a former biochemist and my university studied conotoxins for use as analgesics. Cone snail venom as commonly understood are ion channel blockers. I’ve not heard of what you’re mentioning until now, but when you mention “cone snail venom”, most biology people are thinking of ion channel blockers. This is their primary method of disabling prey.

    If you’re bit by a cone snail and try to drink some soda to counteract the toxin, you’re going to have a bad time. They’re called cigarette snails because you’ve got time to smoke one cig before you die - and not from low blood sugar.

    From your source:

    For example, fish-hunting cone snails use a “motor cabal” to disrupt the propagation of action potentials at the neuromuscular junction. Motor cabal toxins include those that block presynaptic voltage-gated calcium channels (CaV), postsynaptic nicotinic acetylcholine receptors (nAChR), and voltage-gated sodium channels (NaV) on muscle cells6.

    From Wikipedia:

    https://en.wikipedia.org/wiki/Conotoxin

    As of 2005, five biologically active conotoxins have been identified. Each of the five conotoxins attacks a different target: