Mayor Cherelle L. Parker’s administration will break up the oft-criticized Department of Licenses and Inspections, a major reorganization of city government that critics have advocated for years.

During a news conference Thursday, Parker announced that she will separate the agency into two divisions, each with its own commissioner. One department will focus on inspections, safety, and compliance; the other on “quality of life” issues and business code enforcement.

Parker’s news conference marked the second time this week she announced she would split up a city agency. She announced Monday that she is seeking to separate the Streets Department into two distinct operations — one focused on streets, the other on sanitation. Parker said she is not planning to break up any other agencies.