Recently, in this journal, Wu et al. (1) and Gao et al. (2) have both indicated that
host genetic variation related to COVID-19 might be associated to endometrial cancer.
We here add evidence from gene expression analysis supporting that the connection
of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and cancer could
be more general, in line with several other viral infections that represent serious
risks for carcinogenesis in humans. The SARS-CoV-2 has developed similar strategies
to Epstein-Barr virus (EBV) and hepatitis B virus (HSV1) to control p53 by hijacking
the protein via virus antigens, and ultimately leading to its degradation (3, 4).